Managing Sub-Optimal Responders through Combination Therapy
نویسندگان
چکیده
منابع مشابه
Managing hypertension using combination therapy.
Combination therapy of hypertension with separate agents or a fixed-dose combination pill offers the potential to lower blood pressure more quickly, obtain target blood pressure, and decrease adverse effects. Antihypertensive agents from different classes may offset adverse reactions from each other, such as a diuretic decreasing edema occurring secondary to treatment with a calcium channel blo...
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Hypertension is a condition that involves multiple body organs and physiological systems. Maintaining blood pressure (BP) by using one class of drugs that affect one or two systems usually have inadequate response and result in a compensatory or counter-regulatory response from others to blunt the targeted effect of individual drug. For example, starting with diuretics result in initially decre...
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Pulmonary arterial hypertension (PAH) is a complex, progressive disease with several pathobiological mechanisms, including the endothelin, nitric oxide and prostacyclin pathways. Current treatments for PAH target one of these pathways and, in more severe cases or instances of disease worsening, may be combined with a view to target multiple pathways in parallel. Treatment combination is perform...
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BACKGROUND An emphasis on more aggressive lipid-lowering, particularly of low-density lipoprotein cholesterol, to improve patient outcomes has led to an increased use of combination lipid-lowering drugs. This strategy, while potentially beneficial, has triggered concerns regarding fears of adverse effects, harmful drug interactions, and patient nonadherence. OBJECTIVE To present key data rega...
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A recent discussion meeting convened by the Medicines for Malaria Venture examined how best to manage the discovery and preclinical pipeline to achieve novel combination therapies which would address the key clinical needs in malaria. It became clear that dose optimisation of components within combination therapy was a key issue in achieving antimalarial efficacy and for preserving that efficac...
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ژورنال
عنوان ژورنال: Journal of Dental Sleep Medicine
سال: 2016
ISSN: 2333-9756
DOI: 10.15331/jdsm.6246